Steven M Paul Selected Research

Neuroinflammatory Diseases

4/2024	Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy.
1/2023	Regulation of astrocyte lipid metabolism and ApoE secretionby the microglial oxysterol, 25-hydroxycholesterol.
12/2021	A Proinflammatory Stimulus Disrupts Hippocampal Plasticity and Learning via Microglial Activation and 25-Hydroxycholesterol.
6/2020	25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner.
1/2017	ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.

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Steven M Paul Research Topics

Disease

58	Pain (Aches) 01/2024 - 02/2002
56	Alzheimer Disease (Alzheimer's Disease) 03/2024 - 03/2002
43	Fatigue 02/2024 - 02/2008
39	Neoplasms (Cancer) 04/2024 - 10/2002
31	Breast Neoplasms (Breast Cancer) 04/2024 - 05/2010
21	Amyloid Plaque 06/2015 - 03/2002
17	Lung Neoplasms (Lung Cancer) 11/2023 - 08/2015
15	Syndrome (Syndromes) 02/2024 - 11/2009
12	Postoperative Pain 01/2019 - 03/2003
11	Cognitive Dysfunction 04/2024 - 03/2002
11	Peripheral Nervous System Diseases (PNS Diseases) 01/2022 - 01/2018
10	Schizophrenia (Dementia Praecox) 05/2024 - 01/2021
10	Nausea 05/2024 - 06/2005
10	Prostatic Neoplasms (Prostate Cancer) 01/2023 - 02/2008
8	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 01/2024 - 02/2017
7	Constipation 05/2024 - 04/2002
7	Cancer Pain 06/2022 - 02/2002
6	Vomiting 05/2024 - 06/2005
6	Mastodynia 11/2017 - 05/2012
5	Neuroinflammatory Diseases 04/2024 - 01/2017
5	Neoplasm Metastasis (Metastasis) 06/2014 - 02/2002
4	Inflammation (Inflammations) 04/2024 - 09/2002
4	Dyspnea (Shortness of Breath) 02/2024 - 04/2008
4	Head and Neck Neoplasms (Head and Neck Cancer) 11/2015 - 01/2003
3	Tauopathies 04/2024 - 12/2016
3	Neurobehavioral Manifestations 03/2024 - 11/2009
3	Lymphedema (Milroy Disease) 01/2024 - 03/2014
3	Dizziness (Lightheadedness) 05/2023 - 06/2005
3	Mood Disorders (Mood Disorder) 05/2020 - 09/2002
3	Major Depressive Disorder (Major Depressive Disorders) 11/2019 - 08/2014
3	Tinnitus 02/2018 - 01/2018
3	Hearing Loss (Hearing Impairment) 02/2018 - 01/2018
3	Amyloidosis 01/2016 - 10/2004
3	Brain Neoplasms (Brain Tumor) 03/2015 - 01/2012
3	Brain Diseases (Brain Disorder) 05/2011 - 12/2003
3	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 03/2005 - 08/2003
2	Dyspepsia (Indigestion) 05/2024 - 01/2021
2	Psychotic Disorders (Schizoaffective Disorder) 05/2024 - 01/2023
2	Diarrhea 05/2023 - 05/2021
2	Mental Disorders (Mental Disorder) 01/2023 - 01/2013
2	Postpartum Depression (Post-Natal Depression) 05/2020 - 11/2019
2	Anxiety Disorders (Anxiety Disorder) 11/2019 - 01/2013
2	Disease Progression 01/2017 - 09/2002
2	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2016 - 07/2002
2	Chronic Obstructive Pulmonary Disease (COPD) 01/2016 - 04/2008

Drug/Important Bio-Agent (IBA)

24	Amyloid beta-PeptidesIBA 03/2010 - 03/2002
23	Amyloid (Amyloid Fibrils)IBA 01/2017 - 03/2002
22	Apolipoproteins E (ApoE)IBA 06/2020 - 04/2002
21	CytokinesIBA 01/2024 - 09/2002
21	Analgesics (Analgesic Drugs)IBA 01/2020 - 02/2002
16	ApolipoproteinsIBA 01/2019 - 04/2002
16	Proteins (Proteins, Gene)FDA Link 12/2009 - 09/2002
10	Peptides (Polypeptides)IBA 06/2015 - 03/2002
9	xanomelineIBA 05/2024 - 01/2021
9	Opioid Analgesics (Opioids)IBA 01/2017 - 02/2002
7	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 03/2024 - 01/2022
6	Apolipoprotein E4IBA 01/2018 - 12/2002
5	Potassium Channels (Potassium Channel)IBA 04/2024 - 03/2014
5	InterleukinsIBA 01/2023 - 05/2012
5	CholesterolIBA 01/2023 - 09/2003
5	Protein Isoforms (Isoforms)IBA 06/2020 - 04/2002
5	Interleukin-6 (Interleukin 6)IBA 11/2017 - 09/2002
4	Antipsychotic Agents (Antipsychotics)IBA 03/2024 - 03/2006
4	Paclitaxel (Taxol)FDA LinkGeneric 10/2019 - 01/2018
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 11/2017 - 07/2009
4	AntibodiesIBA 12/2016 - 12/2002
4	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2016 - 01/2008
4	Acetaminophen (Paracetamol)FDA LinkGeneric 03/2012 - 07/2004
4	Nalbuphine (Nubain)FDA LinkGeneric 04/2008 - 03/2003
3	Cholinergic Agents (Cholinergics)IBA 05/2023 - 03/2006
3	Interleukin-13IBA 01/2023 - 05/2012
3	Interleukin-10 (Interleukin 10)IBA 01/2023 - 02/2014
3	PlatinumIBA 01/2022 - 01/2018
3	taxaneIBA 01/2022 - 01/2018
3	AntiemeticsIBA 01/2021 - 01/2020
3	LipidsIBA 06/2020 - 09/2003
3	Apolipoprotein E2IBA 01/2018 - 01/2005
3	LigandsIBA 11/2017 - 02/2004
3	Monoclonal AntibodiesIBA 12/2016 - 05/2002
3	Naloxone (Narcan)FDA LinkGeneric 04/2008 - 03/2003
3	Narcotic Antagonists (Opioid Antagonists)IBA 04/2008 - 03/2003
2	Serotonin ReceptorsIBA 01/2023 - 10/2018
2	Neurotransmitter Agents (Neurotransmitter)IBA 01/2023 - 01/2017
2	Tryptophan HydroxylaseIBA 01/2023 - 10/2018
2	Pregnanolone (Allopregnanolone)IBA 05/2020 - 11/2019
2	gamma-Aminobutyric Acid (GABA)IBA 05/2020 - 01/2019
2	brexanoloneIBA 05/2020 - 11/2019
2	NeurosteroidsIBA 11/2019 - 01/2013
2	ChemokinesIBA 11/2017 - 01/2017
2	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 01/2017 - 02/2014
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2017 - 12/2009
2	C-Reactive ProteinIBA 01/2016 - 09/2003

Therapy/Procedure

86	Drug Therapy (Chemotherapy) 02/2024 - 07/2010
28	Radiotherapy 01/2023 - 01/2003
11	Pain Management 05/2023 - 04/2002
11	Therapeutics 12/2021 - 09/2002
5	Tonsillectomy 03/2012 - 07/2004
3	Lymph Node Excision (Lymph Node Dissection) 10/2020 - 02/2013
3	Analgesia 04/2008 - 03/2003
2	Knee Replacement Arthroplasty (Total Knee Replacement) 01/2017 - 01/2016